Unexplained Infertility

Dr. Umme Ruman
Reviewed by Dr. Umme Ruman ,
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This information has been reviewed and approved by an experienced fertility specialist at Indira IVF to provide accurate and up-to-date guidance for our readers.

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Last updated: November 19, 2025

Synopsis

Unexplained infertility affects many couples worldwide. This happens when fertility testing fails to give a reason why one cannot conceive. This is a challenging condition where infertility diagnostic tests appear to be normal, but there are still issues in getting pregnant. Let us take a look in detail at what exactly Unexplained infertility Bangladesh is and all the aspects related to it.

 

Understanding Unexplained Infertility

Unexplained infertility is a medical term that is used when couples are unable to get pregnant even when their fertility test results are normal.

The condition affects couples who have been actively trying to conceive for at least twelve months if the woman is under 35 years old, or six months if she is 35 or older. During this time, despite regular, well-timed intercourse, pregnancy has not occurred even though medical tests suggest no apparent barriers to conception.

Healthcare providers use this diagnosis when standard fertility assessments reveal no structural problems with reproductive organs, normal hormone levels, regular ovulation patterns, open fallopian tubes, adequate egg reserves, and normal sperm parameters. Essentially, all the basic requirements for natural conception appear to be present, yet pregnancy remains unsuccessful.

Factors Affecting Unexplained Infertility

There are many factors involved in Unexplained infertility causes Bangladesh. Some of them may include:

1. Possible Underlying Conditions

  • Undiagnosed medical conditions: Certain health issues like coeliac disease, diabetes, or thyroid disorders can affect fertility in ways that aren't immediately obvious
  • Mild endometriosis: Even minimal endometriosis without symptoms may impact fertility, but can only be definitively diagnosed through surgical procedures
  • Immune system factors: Some immune responses may interfere with conception or implantation processes
  • Genetic factors: Subtle genetic variations might affect reproductive function without being detected by standard genetic screening

2. Quality-Related Issues

  • Egg quality problems: It is still difficult to use current tests to determine the quality of eggs, even though they can be counted.
  • Sperm function issues: Sperm tests can miss identifying problems related either to the sperm or DNA.
  • Problems with the development of embryos: Any issues with the development of embryos that occur following fertilisation may not be visible until the use of assisted reproductive technology.

3. Timing and Environmental Factors

  • Intercourse timing: It is possible that the exact timing of intercourse will not be in sync with the fertile window.
  • Issues with cervical mucus: The quality of cervical mucus may be of low quality or have an unusual character, which can prevent the sperm from penetrating the egg.
  • Problems with the uterine lining: Difficulties in the preparation of the uterine lining may prevent the pregnancy process.

When Should You Consider Unexplained Infertility Testing?

Unexplained infertility testing is needed when:

1. Extended Trying Period

  • Couples under 35 should seek evaluation after 12 months of unsuccessful conception attempts, whilst those 35 and older should consult after 6 months.

2. Regular Menstrual Cycles

  • When periods are regular but pregnancy doesn't occur despite proper timing of intercourse during fertile windows.

3. No Obvious Health Issues

  • Both partners appear healthy and do not have any known medical issues that tend to affect fertility.

4. Previous Pregnancy Success

  • Couples that could previously become pregnant without difficulty, but struggle currently to become pregnant (secondary infertility).

5. Age-Related Concerns

  • Women aged above 30 who struggle with pregnancy could be given an early examination to eliminate fertility issues.

Diagnosis and Testing

It is important to get a proper evaluation of both partners to understand unexplained infertility.

The Diagnostic Timeline

The diagnostic process normally requires several months. It allows physicians to gather extensive data concerning the reproductive health of the two partners. The initial visits are on medical history and basic physical examinations. Subsequently, doctors perform further specific tests based on the situation of every couple.

Testing

Blood tests are normally conducted at certain periods of the menstrual cycle so as to measure the hormone levels accurately. Imaging tests are useful in examining the form and operation of the reproductive organs, and the semen analysis provides valuable data on the male factors of fertility.

Only after this thorough evaluation, when all tests return normal results but conception hasn't occurred, do healthcare providers consider the diagnosis of unexplained infertility. Some providers may recommend additional specialised testing before making the unexplained infertility diagnosis Bangladesh.

Infertility Treatments

The selection of a treatment will rely on factors such as the age of the couple, the duration they have been infertile, their personal preferences and their comfort with different treatments. The unexplained infertility treatment Bangladesh includes:

1. Assisted Reproductive Technologies

Unexplained infertility can be treated best by assisted reproductive technologies (ART). They apply medical procedures in the process of conception in order to increase the probability of a successful pregnancy.

2. Intrauterine Insemination (IUI)

Here, the sperm are washed and concentrated in the laboratory, and then injected directly into the uterus prior to the ovulation process. This avoids issues with cervical mucus and makes good sperm enter the fallopian tubes at the optimal time.

3. In Vitro Fertilisation (IVF)

Unexplained infertility has the highest success rates in in vitro fertilisation (IVF). It operates by initially causing the ovaries to develop multiple eggs, then a surgeon removes them. Sperms are used to fertilise the eggs in the laboratory, and the embryo is reinserted into the uterus.

4. Intracytoplasmic Sperm Injection (ICSI)

IVF may be supplemented with intracytoplasmic sperm injection (ICSI) in case of minor issues with sperm quality. It involves introducing only one sperm directly inside an egg to help fertilisation.

How Long Does Unexplained Infertility Treatment Take?

Treatment of unexplained infertility varies with the approach we take and the response of an individual to the therapies. Initial fertility medications with timed intercourse may be tried for 3-6 cycles before advancing to more intensive treatments.

IUI requires approximately a month per cycle, and before resorting to IVF, most doctors recommend trying 3 to 4 cycles of IUI. The IVF process itself takes approximately 6-8 weeks from start to pregnancy test, including medication preparation, egg retrieval, fertilisation, and embryo transfer phases.

Unexplained Infertility Treatment Cost

Unexplained infertility treatment in Bangladesh varies widely in terms of cost per cycle and clinic. Ovulation induction with monitoring is typically a cost-effective procedure, and IUI is a moderately priced procedure.

IVF is the most comprehensive treatment and is the most expensive due to the use of high-tech and expert personnel. Most clinics offer packages that consist of multiple cycles, which are more economical for couples who require multiple attempts to conceive. To determine your precise treatment cost, consult your doctor and receive a personalised treatment plan with all the costs involved.

What Happens After Unexplained Infertility Treatment?

Following effective treatment, fertility-assisted pregnancies are followed in the same manner as natural ones, where frequent checkups and assistance are applied throughout the entire pregnancy.

Couples might have to undergo numerous treatment sessions before finding a way to get pregnant. The success rates tend to be good, and most of the couples are able to become pregnant after making repeated attempts and receiving appropriate medical help.

Conclusion

Having unexplained infertility can be frustrating, but this is not a barrier to becoming a parent. Infertility in many couples is unexplained, and seeking early help can make a difference. With different treatment options available, many couples with unexplained infertility eventually achieve their goals of parenthood.

It is important to work with experienced infertility experts at Indira IVF for a successful pregnancy. Apart from that, you need to be open to different treatment options and maintain hope throughout this journey. Through good unexplained infertility support Bangladesh, good medical care, and persistence, most couples with unexplained infertility will be able to have healthy pregnancies.

Frequently Asked Questions

How long should we try to conceive before seeking medical help?

Does unexplained infertility mean we'll never have children naturally?

Are fertility treatments safe for unexplained infertility?

Can lifestyle changes alone help with unexplained infertility?

Is it worth getting a second opinion for unexplained infertility?

How do we decide which treatment to try first?

Meet Top Fertility Specialists in Bangladesh at Indira IVF

Dr. Umme Ruman

Chief Infertility Specialist, MBBS(DU), FCPS(Obstetrics and Gynaecology), Fellowship in Assisted reproduction

Dr. Umme Ruman is a BMDC-registered infertility specialist based in Dhaka. She holds advanced qualifications in assisted reproductive techniques, sexual and reproductive medicine. Dr. Ruman serves as a Chief Consultant at Indira IVF Dhaka, helping patients with personalised fertility care based on her vast experience and expertise. Her knowledge and compassion will support couples navigating reproductive health challenges and guide them effectively towards their parenthood dreams.

Dr. Rezwana Kabir

IVF specialist, MBBS (SSMC), MS (Obstetrics and Gynaecology), Fellowship in Assisted reproduction

Dr. Rezwana Kabir is a BMDC-registered specialist in obstetrics and gynaecology, and now a part of Indira IVF’s team of fertility specialists in Bangladesh. She combines medical proficiency with a patient-centric approach, offering tailored solutions to couples seeking fertility assistance. She is committed to helping individuals confidently navigate the journey to parenthood through ethical, empathetic, and evidence-based care.

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